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NDT Advance Access originally published online on December 10, 2008
Nephrology Dialysis Transplantation 2009 24(3):1057-1062; doi:10.1093/ndt/gfn741
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Hermann Senator and albuminuria—forgotten pioneering work in the 19th century

Ron T. Gansevoort1 and Eberhard Ritz2

1 University Medical Center Groningen, University of Groningen, The Netherlands 2 Ruperto-Carola-University, Heidelberg, Germany

Correspondence and offprint requests to: Eberhard Ritz, Nierenzentrum, Im Neuenheimer Feld 162, D 69120 Heidelberg, Germany. Tel: +49-6221-601705; Fax: +49-6221-603302; E-mail: prof.e.ritz{at}t-online.de



  Abstract

Testing urinary albumin concentration by immune detection methods has recently turned out to be a highly rewarding procedure, as low level albumin excretion has turned out to be a powerful predictor of cardiovascular and renal risk in diabetic and nondiabetic patients. In the following we discuss a text dating back to the 19th century in order to make today's nephrologists aware of the remarkable and prescient, but meanwhile completely forgotten investigations on urinary albumin excretion in individuals without primary kidney disease. The treatise of Hermann Senator convincingly disproved the then held dogma that albuminuria was always a sign of primary renal disease. These observations are all the more remarkable since he was forced to use relatively simple and not absolutely specific methods. He further provided an explanation of the renal handling of albumin which to a large extent is still valid today.

Keywords: albuminuria without kidney disease; albuminuria; glomerular filtration; history; microalbuminuria

Dedicated to one of the pioneers of modern albuminuria research in diabetes, a close friend and teacher, Carl-Erik Mogensen(Aarhus/Denmark)

Received for publication: 8. 7.08
Accepted in revised form: 7.11.08


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