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NDT Advance Access originally published online on November 21, 2008
Nephrology Dialysis Transplantation 2009 24(2):578-588; doi:10.1093/ndt/gfn464
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© The Author [2008].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org


Baseline characteristics of an incident haemodialysis population in Spain: results from ANSWER—a multicentre, prospective, observational cohort study

Rafael Pérez-García1, Alejandro Martín-Malo2, Joan Fort3, Xavier Cuevas4, Fina Lladós5, Javier Lozano5, Fernando García6 and on behalf of all Investigators from the ANSWER study

1 Servicio de Nefrologia, Hospital Gregorio Marañón, Madrid 2 Servicio de Nefrologia, Hospital Reina Sofia, Cordoba 3 Servicio de Nefrologia, Hospital Vall d’Hebron 4 Servicio de Nefrologia, Hospital Consorci Sanitari de Terrassa 5 Amgen S.A., Barcelona 6 Unidad de Epidemiología Clinica, Hospital Puerta de Hierro, Madrid, Spain

Correspondence and offprint requests to: Rafael Pérez-García, Servicio de Nefrología, Hospital Gregorio Marañón, C/Doctor Esquerdo, 46-28007 Madrid, Spain. Tel: +34-915-86-80-47; Fax: +34-915-86-83-18; E-mail: rperezgarcia{at}senefro.org



  Abstract

Background. The ANSWER study aims to identify risk factors leading to increased cardiovascular morbidity and mortality in a Spanish incident haemodialysis population. This paper summarizes the baseline characteristics of this population.

Methods. A prospective, observational, one-cohort study, including all consecutive incident haemodialysis patients from 147 Spanish nephrology services, was conducted. Patients were enrolled between October 2003 and September 2004. Sociodemographic, clinical, laboratory and health care characteristics were collected.

Results. Baseline characteristics are described for 2341 incident haemodialysis patients [mean (SD) age 65.2 (14.5) years, 63% males]. The main cause of renal failure was diabetic nephropathy (26%). The majority of patients (57%) had a Karnofsky score of 80–100 and 27% were followed up by a nephrologist for ≤6 months. In total, 86% of the patients had hypertension, 43% had dyslipidaemia and 44% had a history of cardiovascular disease. Initial vascular access was obtained via a temporary catheter in 30% of patients, via a permanent catheter in 16% and via an arteriovenous fistula in 54%. Albumin levels were <3.5 g/dl in 43% of patients. Immediately prior to the onset of haemodialysis, the mean (SD) glomerular filtration rate (GFR) was 7.6 (2.8) ml/min/1.73 m2, and only 6.7% of the patients were within the K/DOQI guidelines for all four bone mineral markers. In addition, a high proportion of patients had anaemia markers outside the EBPG guidelines (haemoglobin <11 g/dl, 59%, ferritin <100 or >500 ng/ml, 41% and saturated transferrin <20 or >40%, 50%) despite previous treatment with erythropoiesis-stimulating agents in 41% of cases.

Conclusions. There is excessive use of temporary catheters and a high prevalence of uraemia-related cardiovascular risk factors among incident haemodialysis patients in Spain. The poor control of hypertension, anaemia, malnutrition and mineral metabolism and late referral to a nephrologist indicate the need for improving the therapeutic management of patients before the onset of haemodialysis.

Keywords: cardiovascular; haemodialysis; malnutrition; risk factors; vascular access

Received for publication: 21.12.07
Accepted in revised form: 22. 7.08


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