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NDT Advance Access originally published online on July 22, 2009
Nephrology Dialysis Transplantation 2009 24(10):3247-3250; doi:10.1093/ndt/gfp364
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Lanthanum deposition in a dialysis patient

Richard L. Davis and Jerrold L. Abraham

Department of Pathology, Suny Upstate Medical University, Syracuse, NY 13210, USA

Correspondence and offprint requests to: Jerrold L. Abraham; E-mail: abrahamj{at}upstate.edu



  Abstract

Lanthanum carbonate (LaCO3) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenteric lymph node at autopsy of a 38-year-old female ESRD patient 3 years following LaCO3 administration. Although LaCO3 is generally thought to be minimally absorbed, this demonstration suggests the need for further investigation of the extent and potential effects of such absorption.

Keywords: end-stage renal disease; lanthanum; lymph node; scanning electron microscopy/energy dispersive x-ray spectroscopy

Received for publication: 17. 6.09
Accepted in revised form: 1. 7.09


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