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NDT Advance Access originally published online on July 13, 2009
Nephrology Dialysis Transplantation 2009 24(10):3245-3247; doi:10.1093/ndt/gfp340
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


A confusional state associated with use of lanthanum carbonate in a dialysis patient: a case report

Clotilde Muller, Francois Chantrel and Bernadette Faller

Department of Nephrology, Hospital Pasteur, France

Correspondence and offprint requests to: Clotilde Muller; E-mail: clotilde-muller{at}hotmail.fr



  Abstract

A 75-year-old woman was admitted with febrile confusion and abdominal pain. She was taking medications that included lanthanum carbonate. Examination, biology, a cerebral scan, and a review of her medications could not explain the confusion. The plain film of the abdomen revealed multiple diffuse calcium-like deposits throughout the digestive tract. The plasma levels of lanthanum were higher than normal. The confusion resolved after discontinuation of the lanthanum carbonate.

This case raises the problem of the potential role played by lanthanum tablet residue in the genesis or aggravation of diverticular flare-up and the problem of the potential permeability of the blood–brain barrier with lanthanum use in case of its digestive accumulation, leading to increased serum concentrations.

Keywords: adverse event; confusion; therapeutic

Received for publication: 25. 5.09
Accepted in revised form: 22. 6.09


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This article has been cited by other articles:


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M. D. L. Smyth and R. D. Pratt
A confusional state associated with use of lanthanum carbonate in a dialysis patient: a case report
Nephrol. Dial. Transplant., December 1, 2009; 24(12): 3898 - 3899.
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J. L. Abraham
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Nephrol. Dial. Transplant., November 17, 2009; (2009) gfp545v2.
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