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NDT Advance Access originally published online on December 8, 2007
Nephrology Dialysis Transplantation 2008 23(3):1019-1025; doi:10.1093/ndt/gfm738
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Troponin T is an independent predictor of mortality in renal transplant recipients

Grainne M. Connolly1, Ronan Cunningham2, Peter T. McNamee2, Ian S. Young1 and Alexander P. Maxwell2

1 Department of Clinical Biochemistry, Royal Victoria Hospital 2 Department of Nephrology, Belfast City Hospital, Belfast, Northern Ireland BT12 6BA, UK

Dr Grainne Connolly, Department of Clinical Biochemistry, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland BT12 6BA, UK. Tel: +44-2890240503; Fax: +44-2890234029; E-mail: Grainne.Connolly{at}bll.n-i.nhs.uk



  Abstract

Background. Numerous reports have demonstrated an association between elevated Troponin T levels and adverse cardiovascular outcomes in patients with chronic kidney disease. However, whether raised Troponin T levels are an independent predictor of mortality in renal transplant recipients has not yet been established. The aim of this study was, therefore, to assess the use of Troponin T as a prognostic marker in a population of renal transplant recipients.

Methods. Three hundred and seventy-two asymptomatic renal transplant recipients were recruited between June 2000 and December 2002. Troponin T was measured at baseline and prospective follow-up data were collected at a median of 1739 days.

Results. In Kaplan-Meier analysis a Troponin T level ≥0.03 µg/l was a significant predictor of mortality (P < 0.001). In Cox Regression analysis, an elevated Troponin T level remained a significant predictor of mortality following adjustment for traditional cardiovascular risk factors (P < 0.001) and following adjustment for estimated glomerular filtration rate and high sensitivity C reactive protein (P < 0.001).

Conclusions. Elevated Troponin T level is a strong independent predictor of all cause mortality in patients with a renal transplant. Troponin T, therefore, represents a promising biochemical marker that identifies those renal transplant recipients who are most likely to benefit from aggressive cardiovascular risk factor modification.

Keywords: cardiovascular disease; cardiovascular events; renal transplantation; risk factors; survival

Received for publication: 2. 1.07
Accepted in revised form: 20. 9.07


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 Nephrol Dial TransplantHome page
G. R. Shroff and B. L. Kasiske
Troponin T is an independent predictor of mortality in renal transplant recipients
Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2707 - 2707.
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G. Connolly
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Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2707 - 2708.
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