Skip Navigation


NDT Advance Access originally published online on October 2, 2007
Nephrology Dialysis Transplantation 2008 23(2):654-658; doi:10.1093/ndt/gfm640
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
23/2/654    most recent
gfm640v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stassen, P. M.
Right arrow Articles by Stegeman, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stassen, P. M.
Right arrow Articles by Stegeman, C. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Influenza vaccination does not result in an increase in relapses in patients with ANCA-associated vasculitis

Patricia M. Stassen1, Jan-Stephan F. Sanders2, Cees G. M. Kallenberg2 and Coen A. Stegeman1

1Department of Nephrology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands and 2Department of Clinical Immunology, University Medical Center Groningen, University of Groningen,PO Box 30001, 9700 RB, Groningen, The Netherlands

Correspondence and offprint requests to: Patricia M. Stassen, Department of Internal Medicine, Medisch Spectrum Twente, PO Box 50000, 7500 KA, Enschede, The Netherlands. Tel: +4619142; Fax: +31534619142; E-mail: p.m.stassen{at}int.umcg.nl



  Abstract

Background. Vaccination against influenza has been suggested to induce relapses of ANCA-associated vasculitis but evidence is lacking. In this study, we assessed whether vaccination against influenza increases the occurrence of relapses in patients with ANCA-associated vasculitis.

Methods. Two hundred and thirty consecutive patients with ANCA-associated vasculitis from our out-patient clinics of a tertiary referral center, with at least 1 year of follow-up, were included. Retrospectively, the relapse rate per 100 patients at risk in patients who had been vaccinated against influenza within the preceding year and in patients who not had been vaccinated within that time period were calculated.

Results. The relapse rate per 100 patients at risk was lower in patients who had been vaccinated against influenza (3.4) than in patients who had not been vaccinated (6.3), when analyzed for the entire year and for every quarter of the year. Also, the disease-free survival per separate year according to the vaccination status was lower in all 5 years in patients who had been vaccinated, being statistically significant in 2 years.

Conclusion. Vaccination against influenza does not increase the relapse rate in patients with ANCA-associated vasculitis.

Keywords: ANCA-associated vasculitis; influenza; vaccination; relapse; autoimmune disease

Received for publication: 1. 8.07
Accepted in revised form: 21. 8.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.