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NDT Advance Access originally published online on November 28, 2007
Nephrology Dialysis Transplantation 2008 23(2):608-611; doi:10.1093/ndt/gfm736
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy

Aisling E. Courtney1,2, Peter T. McNamee2, Shirley Heggarty3, Derek Middleton4 and A. Peter Maxwell1,2

1Nephrology Research Group, Queen's University Belfast, 2Regional Nephrology Unit, 3Genomics Core Facility, School of Medicine, Queen's University Belfast, Regional Genetics Centre, and 4Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast BT9 7AB, UK

Correspondence and offprint requests to: Dr Aisling E. Courtney, Regional Nephrology Unit, Belfast City Hospital-Level 11, Lisburn Road, Belfast BT9 7AB, UK. Tel: +44-2890329241; Fax: +44-2890263535; E-mail: aecourtney{at}doctors.org.uk



  Abstract

Background. Haem oxygenase-1 (HO-1) is a cytoprotective molecule that is reported to have a protective role in a variety of experimental models of renal injury. A functional dinucleotide repeat (GT)n polymorphism, within the HO-1 promoter, regulates HO-1 gene expression; a short number of repeats (S-allele <25) increases transcription. We report the first assessment of the role of this HO-1 gene promoter polymorphism in chronic kidney disease due to autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IgAN).

Methods. The DNA from 160 patients (99% Caucasian) on renal replacement therapy (RRT) was genotyped. The primary renal disease was ADPKD in 100 patients and biopsy-proven IgAN in 60 patients.

Results. Overall, the mean age at commencement of RRT was not significantly different between patients with and without an S-allele (44.1 years versus 45.0 years, P = 0.64). In patients with ADPKD, the age at commencement of RRT was comparable regardless of the HO-1 genotype (47.7 years versus 46.7 years, P = 0.59). The same was true in patients with IgAN (38.3 years versus 42.2 years, P = 0.28).

Conclusion. This suggests that the functional HO-1 promoter polymorphism does not influence renal survival in CKD due to ADPKD or IgAN.

Keywords: gene polymorphism; haem oxygenase-1; IgA nephropathy; polycystic kidney disease; progression of kidney disease

Received for publication: 6. 8.07
Accepted in revised form: 19. 9.07


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