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NDT Advance Access originally published online on May 8, 2008
Nephrology Dialysis Transplantation 2008 23(10):3337-3342; doi:10.1093/ndt/gfn246
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Prevalence of abnormal glucose metabolism in Chinese renal transplant recipients: a single centre study

Hoi Wong Chan, Chi Yuen Cheung, Yan Lun Liu, Yiu Han Chan, Ho Sing Wong, Wai Leung Chak, Koon Shing Choi, Ka Foon Chau and Chun Sang Li

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China SAR

Dr Chi Yuen Cheung, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, China SAR. Tel: +82-852-29588888; E-mail: simoncycheung{at}gmail.com



  Abstract

Background. Post-transplant diabetes mellitus (PTDM) after renal transplantation is associated with adverse outcome on patient and graft survival. Fasting blood glucose alone will underestimate diabetes and also ignores diagnosis of impaired glucose tolerance (IGT). IGT has a strong correlation with diabetes and cardiovascular risk.

Methods. In this cross-sectional study, we estimate the prevalence of abnormal glucose metabolism (AGM) using oral glucose tolerance test (OGTT) and identify its predictive factors. Patients who received kidney transplantation in our centre without pre-transplant diabetes were recruited. OGTT was performed in patients with fasting glucose levels between 5.6 and 6.9 mmol/L for at least two occasions 6 months post-transplantation.

Results. Of 119 patients recruited, 31 had OGTT performed. The prevalence of PTDM, IGT and IFG was 21.8 (26/119)%, 6.7 (8/119)% and 3.4 (4/119)% respectively. Thus the overall prevalence of AGM was 31.9%. Age (P = 0.003), body mass index (P = 0.032), hepatitis B seropositivity status (P = 0.01), CMV infection (P = 0.02) and acute rejection (P = 0.002) were all associated with development of AGM. Using multivariate analysis, only older age at transplant (OR 1.09), history of acute rejection (OR 3.40) and hepatitis B seropositivity (OR 3.13) were significantly associated with the development of AGM.

Conclusion. AGM is common in our renal transplant recipients.

Keywords: abnormal glucose metabolism; renal transplant

Received for publication: 9. 2.08
Accepted in revised form: 10. 4.08


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