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NDT Advance Access originally published online on August 17, 2007
Nephrology Dialysis Transplantation 2008 23(1):364-368; doi:10.1093/ndt/gfm528
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation

Noora S. Alakulppi1, Lauri E. Kyllönen2, Jukka Partanen1, Kaija T. Salmela2 and Jarmo T. Laine1

1Research and Development, Finnish Red Cross Blood Service, Kivihaantie 7 and 2Renal Transplant Unit, Helsinki University Hospital, Kasarminkatu 11-13, FI-00130 Helsinki, Finland

Correspondence to: Jarmo Laine, Kivihaantie 7, Research and Development, Finnish Red Cross Blood Service, FI-00310 Helsinki, Finland. Email: jarmo.laine{at}veripalvelu.fi



  Abstract

Background. Acute rejection episodes and vascular complications are common after renal transplantation and have negative impact on the long-term patient and graft survival. We investigated whether the risks of acute rejection, thrombosis, infarction and graft loss could be predicted based on the presence of functional polymorphisms in the genes of the coagulation and endothelial inflammation cascade.

Methods. The study consisted of 772 consecutive cadaver kidney transplantations from a single centre. The effects of gene polymorphisms FVL, F5R2, FII G20210A, MTHFR C677T, F13A1 V34L, TFPI P151L, PROC W380G, TNF G(-308)A, IL10 A(-592)C, IL10 A(-1082)G and IL6 C(-174)G of recipients and donors were investigated.

Results. We were unable to find statistically significant associations between any of the studied polymorphisms and clinical outcomes.

Conclusions. Our results indicate that high-risk renal transplant candidates cannot be identified through the routine analysis of the polymorphisms.

Keywords: infarction; kidney transplantation; polymorphism; rejection; thrombosis

Received for publication: 10. 5.07
Accepted in revised form: 11. 7.07


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