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NDT Advance Access originally published online on August 17, 2007
Nephrology Dialysis Transplantation 2007 22(12):3646-3651; doi:10.1093/ndt/gfm487
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Importance of renal mass on graft function outcome after 12 months of living donor kidney transplantation

João Batista Douverny, José Carlos Baptista-Silva, José Osmar Medina Pestana and Ricardo Sesso

Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil

Correspondence to: Dr João Batista Douverny. Av. Imperatriz Leopoldina 303 apt. 64, São Paulo, SP, Brazil, 09770-271. Email: jbdouverny{at}uol.com.br



  Abstract

Background. Few studies have directly measured the kidney weight and investigated donor parameters related to it. The aim of this study was to evaluate the kidney weight and its relationship to creatinine clearance (CrCl) after 12 months post-transplantation.

Methods. A total of 123 recipients of renal transplantation from living donors were evaluated. Demographic and anthropometric data from donors and recipients were collected in the pre-operative phase. Data about kidney weight were obtained through kidney measurement using an electronic weighing machine at the moment of transplantation. Glomerular filtration rate (GFR) was estimated through CrCl (modification of diet in renal disease formula) at the 1st, 6th, 12th and 18th month post-transplantation.

Results. The mean value of kidney weight was 170 ± 31 g (166.4 ± 29.2 g in women and 177.5 ± 32.5 g in men). The kidney weight had a correlation with the donor's BMI (r = 0.43, P < 0.001) and with the CrCl on the 12th month (r = 0.31, P = 0.001). Using multiple linear regression, the kidney weight could be predicted through the BMI and donor's gender (R2 = 0.21; P < 0.01). The CrCl after 12 months had a significant correlation with the graft weight/recipient weight ratio and with the donor age (R2 = 0.22; P < 0.01).

Conclusion. The kidney weight can be estimated using the donor's gender and BMI. The kidney weight significantly influences the CrCl 12 months after transplantation.

Keywords: graft function; kidney transplantation; kidney weight; living donor; renal mass

Received for publication: 2. 4.07
Accepted in revised form: 26. 6.07


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