Skip Navigation


NDT Advance Access originally published online on June 2, 2007
Nephrology Dialysis Transplantation 2007 22(11):3191-3195; doi:10.1093/ndt/gfm346
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
22/11/3191    most recent
gfm346v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Oortwijn, B. D.
Right arrow Articles by van Kooten, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oortwijn, B. D.
Right arrow Articles by van Kooten, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Demonstration of secretory IgA in kidneys of patients with IgA nephropathy

Beatrijs D. Oortwijn1, Maria Pia Rastaldi3, Anja Roos1,2, Deborah Mattinzoli3, Mohamed R. Daha1 and Cees van Kooten1

1Department of Nephrology and 2Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands and 3Renal Immunopathology Laboratory. Fondazione D’Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, c/o San Carlo Borromeo Hospital, Milano, Italy

Correspondence and offprint requests to: Cees van Kooten, LUMC, Department of Nephrology, C3-P, Albinusdreef 2 2333 ZA Leiden, The Netherlands. Email: kooten{at}lumc.nl



  Abstract

Background. Recently we reported a possible role for secretory IgA (SIgA) in IgA nephropathy (IgAN), as suggested by increased serum levels in patients with active disease and accumulation of SIgA in a glomerular eluate. Therefore, we attempted to find support for these findings by analysis of the presence of SIgA in biopsies of IgAN patients.

Methods. Renal biopsies of 26 patients with biopsy-proven IgAN were analysed for the presence of SIgA and complement proteins.

Results. In 15% mesangial deposition of SIgA was demonstrated, using a specific staining for secretory component (SC) and colocalization with IgA. The presence of SIgA in these biopsies showed a strong correlation with deposition of mannose-binding lectin (MBL) and C4d. Moreover, we observed a strong colocalization between SIgA and MBL or C4d. This local complement activation has previously been linked to more severe renal disease.

Conclusions. Therefore, these data provide additional evidence for a pathogenic role for SIgA in IgA nephropathy.

Keywords: IgA nephropathy; IgA; SIgA; MBL; C4d

Received for publication: 24.12.06
Accepted in revised form: 4. 5.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.