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NDT Advance Access originally published online on June 5, 2007
Nephrology Dialysis Transplantation 2007 22(11):3115-3121; doi:10.1093/ndt/gfm151
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Review on uraemic solutes II—Variability in reported concentrations: causes and consequences

Raymond Vanholder1, Nathalie Meert1, Eva Schepers1, Griet Glorieux1, Angel Argiles2, Philippe Brunet3, Gerald Cohen4, Tilman Drüeke5, Harald Mischak6, Goce Spasovski7, Ziad Massy8, Joachim Jankowski9 and for the European Uremic Toxin Work Group (EUTox)

1Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium,2RD Néphrologie et Néphrologie Dialyse St Guilhem and University Hospital Montpellier,3INSERM 608, Aix Marseille Université, Centre de Néphrologie et Transplantation rénale, Assistance Publique – Hôpitaux de Marseille, France,4Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria,5INSERM Unit 507 and Division of Nephrology, Necker Hospital, Paris, France,6Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany,7Department of Nephrology, University Clinical Center, University of Skopje, Macedonia,8INSERM ERI-12, Amiens, and Amiens University Hospital, UPJV, Amiens, France and9Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin Medizinische Klinik IV, Germany

Correspondence and offprint requests to: Dr Raymond Vanholder, Nephrology Section, 0K12, University Hospital, De Pintelaan 185, B9000. Ghent, Belgium. Email: raymond.vanholder{at}ugent.be



  Abstract

The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; these deviations, if not perceived or handled appropriately, may lead to incorrect interpretations of the pathophysiological role of uraemic solutes and/or to erroneous therapeutic decisions. To come to an objective approach towards this problem, variability analysis of reported concentrations may be of help. Striking outliers should either be discarded or considered together with other values which are more consistent with the majority of reported data.

Keywords: uraemia; uraemia toxins; uraemia toxicity; urronic kidney failure

Received for publication: 12.12.06
Accepted in revised form: 27. 2.07


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