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NDT Advance Access originally published online on September 27, 2006
Nephrology Dialysis Transplantation 2007 22(1):224-228; doi:10.1093/ndt/gfl540
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Peritoneal transport characteristics and dwelling time significantly impact ghrelin clearance in peritoneal dialysis patients

Chia-Chu Chang1,5, Ching-Hui Hung2, Hung-Lin Chen4, Kai-Lin Hwang6 and Ching-Yuang Lin3,5

1Nephrology Division and 2Cardiac Division, Department of Internal Medicine, 3Department of Pediatrics, 4Department of Medical Nutrition Therapy & Food Service, Changhua Christian Hospital, Changhua, 5College of Health Sciences, Institute of Medical Research, Chang Jung Christian, Tainan and 6Department of Public Health, Chung Shan Medical University, Taichung, Taiwan

Correspondence and offprint requests to: Ching-Yuang Lin, MD, PhD, Department of Pediatrics, Children's Hospital, Changhua Christian Hospital, No. 135 Nan-Shiao Street, Changhua, 500, Taiwan. Email: 100966{at}cch.org.tw



  Abstract

Background. Plasma ghrelin exerts widespread bioactivities. Although it is effectively removed from the blood by a single course of haemodialysis, peritoneal clearance of ghrelin is uncertain. Our study aimed to determine (i) whether there is a correlation between plasma ghrelin levels and characteristics of peritoneal ghrelin clearance, and (ii) whether plasma ghrelin levels significantly impact markers of mortality or morbidity in continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods. We enrolled 50 qualified CAPD patients. Blood was drawn during the fasting state and 2 h post-prandially. Also during these periods, peritoneal effluents were collected for radioimmunoassay of total plasma ghrelin level and measurement of other parameters. Twenty-four hour ascites were collected for determination of ghrelin daily mass transfer.

Results. Peritoneal ghrelin clearance was positively correlated with the dialysate-peritoneal creatinine (D/PCr) ratio. Fasting plasma ghrelin levels were inversely correlated with the peritoneal/plasma (D/Pghrelin) ratio (P = 0.045). Plasma ghrelin levels were negatively correlated with body mass index, waist-hip ratio, fasting insulin and triglyceride level, and positively correlated with lean body mass. Plasma ghrelin levels were positively correlated with left ventricular mass (LVM), left ventricular mass index and blood pressure.

Conclusions. Peritoneal transporter characteristics may modulate plasma ghrelin levels in CAPD subjects. By contributing to the level of plasma ghrelin, dwelling time may have an impact on LVM and associated morbidity in CAPD patients.

Keywords: continuous peritoneal ambulatory dialysis; left ventricular mass; plasma ghrelin; visual analogue scales


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