NDT Advance Access originally published online on March 8, 2006
Nephrology Dialysis Transplantation 2006 21(7):1855-1862; doi:10.1093/ndt/gfl073
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Original Articles: Clinical Nephrology
Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function
1 Department of Nephrology and 2 Department of Nuclear Medicine, Clinical Department of Internal Medicine and 3 Department of Clinical Chemistry, Teaching Hospital Maribor, Maribor, Slovenia
Correspondence and offprint requests to: Prof. Radovan Hojs, MD, PhD, Splo
na bolninica Maribor, Klini
ni oddelek za interno medicino, Oddelek za nefrologijo, Ljubljanska 5, 2000 Maribor, Slovenia. Email: Radovan.Hojs{at}sb-mb.si
Background. Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with chronic kidney disease (CKD). Recently, serum cystatin C was proposed as a new endogenous marker of GFR and in our study its diagnostic accuracy was compared with that of other markers of GFR.
Methods. In this study, 164 patients with CKD stages 2–3 (GFR 30–89 ml/min/1.73 m2), who had performed 51Cr-labelled ethylenediaminetetra-acetic acid clearance, were enrolled. In each patient, serum creatinine and serum cystatin C were determined. Creatinine clearance was calculated using the Cockcroft–Gault (C&G) and the modification of diet in renal disease (MDRD) formulas.
Results. The mean 51CrEDTA clearance was 57 ml/min/1.73 m2, the mean serum creatinine 149 µmol/l and the mean serum cystatin C 1.74 mg/l. We found significant correlation between 51CrEDTA clearance and serum creatinine (R = –0.666), serum cystatin C (R = –0.792), reciprocal of serum creatinine (R = 0.628), reciprocal of serum cystatin C (R = 0.753) and calculated creatinine clearance from the formulas C&G (R = 0.515) and MDRD formulas (R = 0.716). The receiver operating characteristic (ROC) curve analysis (cut-off for GFR 60 ml/min/1.73 m2) showed that serum cystatin C had a significantly higher diagnostic accuracy than serum creatinine (P = 0.04) and calculated creatinine clearance from the C&G formula (P<0.0001), though only in female patients. No difference in diagnostic accuracy was found between serum cystatin C and creatinine clearance calculated from the MDRD formula.
Conclusions. Our results indicate that serum cystatin C is a reliable marker of GFR in patients with mildly to moderately impaired kidney function and has a higher diagnostic accuracy than serum creatinine and calculated creatinine clearance from the C&G formula in female patients.
Keywords: 51CrEDTA clearance; chronic kidney disease; glomerular filtration rate; serum creatinine; serum cystatin C
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Wu and C. R. Parikh Screening for Kidney Diseases: Older Measures versus Novel Biomarkers Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1895 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. MacGregor How common is early chronic kidney disease?: A Background Paper prepared for the UK Consensus Conference on Early Chronic Kidney Disease Nephrol. Dial. Transplant., September 1, 2007; 22(suppl_9): ix8 - ix18. [Full Text] [PDF]
|
|
|
|
|
|
O. Toprak, M. Cirit, M. Yesil, S. Bayata, M. Tanrisev, U. Varol, R. Ersoy, and E. Esi Impact of diabetic and pre-diabetic state on development of contrast-induced nephropathy in patients with chronic kidney disease Nephrol. Dial. Transplant., March 1, 2007; 22(3): 819 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Bachorzewska-Gajewska, J. Malyszko, E. Sitniewska, J. S. Malyszko, and S. Dobrzycki Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography Nephrol. Dial. Transplant., January 1, 2007; 22(1): 295 - 296. [Full Text] [PDF]
|
|