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NDT Advance Access originally published online on February 20, 2006
Nephrology Dialysis Transplantation 2006 21(5):1184-1187; doi:10.1093/ndt/gfl016
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Hypothesis

Coxsackie B viruses and the kidney—a neglected topic

Andreas Pasch and Felix J. Frey

Department of Nephrology and Hypertension, Inselspital, University of Bern, Freiburgstrasse 10, CH-3010 Bern, Switzerland

Correspondence and offprint requests to: Andreas Pasch, MD, Department of Nephrology and Hypertension, Inselspital, University of Bern, Freiburgstrasse 10, CH-3010 Bern, Switzerland. Email: andreas.pasch{at}insel.ch

Coxsackie B viruses types 1–6 (CVB1–6) occur worldwide and cause a broad spectrum of diseases, including myocarditis and aseptic meningitis. Although renal damage due to CVB has been suspected since the 1950s, these agents are only rarely searched for in today's clinical nephrological practice. Nevertheless, CVB can infect mesangial cells. Furthermore, infections with these viruses lead to a histological picture resembling mesangioproliferative glomerulonephritis and IgA-nephropathy in mice. In the present article, we provide an overview of this largely neglected topic, and of the slowly and steadily increasing evidence suggesting a link between coxsackieviral infections and kidney diseases.

Keywords: coxsackievirus; CVB; enterovirus; mesangial; renal


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