Skip Navigation


NDT Advance Access originally published online on November 22, 2005
Nephrology Dialysis Transplantation 2006 21(3):736-742; doi:10.1093/ndt/gfi280
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/3/736    most recent
gfi280v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tkaczyk, M.
Right arrow Articles by Zurowska, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tkaczyk, M.
Right arrow Articles by Zurowska, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Original Articles: Dialysis and Transplantation

Hypertension in dialysed children: the prevalence and therapeutic approach in Poland—a nationwide survey

Marcin Tkaczyk1, Michal Nowicki1, Irena Balasz-Chmielewska2, Hanna Boguszewska-Baczkowska3, Dorota Drozdz4, Barbara Kollataj5, Tomasz Jarmolinski6, Katarzyna Jobs3, Katarzyna Kilis-Pstrusinska7, Beata Leszczynska8, Irena Makulska7, Dariusz Runowski9, Roman Stankiewicz10, Maria Szczepanska11, Ryszard Wiercinski12, Ryszard Grenda3, Andrzej Kanik13, Jacek A. Pietrzyk4, Maria Roszkowska-Blaim8, Krystyna Szprynger11, Jacek Zachwieja9, Maria M. Zajaczkowska5, Walentyna Zoch-Zwierz12, Danuta Zwolinska7 and Aleksandra Zurowska2

1 Department of Nephrology and Dialysis, Polish Mother's Memorial Hospital Research Institute of Lódz and Pediatric Dialysis Centers in 2 Gdansk, 3 Warszawa (IP CZD), 4 Kraków, 5 Lublin, 6 Szczecin, 7 Wroclaw, 8 Warszawa (AM), 9 Poznan, 10 Torun, 11 Zabrze, 12 Bialystok and 13 Rzeszów, Poland

Correspondence and offprint requests to: Marcin Tkaczyk, MD, Department of Nephrology and Dialysis, Polish Mother's Memorial Hospital Research Institute, 281/289 Rzgowska St, 93-338 Lódz, Poland. Tel: ++48 42 2712001, Fax: ++48 42 2711381, Email: mtkaczyk{at}uni.lodz.pl

Background. The aim of this nationwide analysis was to assess the incidence and current treatment profile of arterial hypertension in children undergoing chronic haemodialysis or peritoneal dialysis and attitudes of paediatric nephrologists towards the choice of antihypertensive drugs in their patients.

Methods. The study group consisted of 134 children (89 males, 45 females, mean age 10.7±5 years) from all 13 paediatric dialysis centres in Poland. The data were gathered through a questionnaire for each patient dialysed in November 2004.

Results. The overall incidence of hypertension in the study group was 55% (74 of 134 patients; 47 males, 27 females). The incidence rate was similar in boys and girls (53 vs 60%) and in those on haemodialysis and peritoneal dialysis (56 vs 54%). Chronic glomerulonephritis as an underlying renal disease was significantly more frequent in the hypertensive than in the normotensive subjects (37 vs 10%, P = 0.004). Residual urine output was higher in normotensives (41 vs 10 ml/kg body weight; P<0.001). Among those treated with antihypertensives: 32% were treated by monotherapy, 36% received two drugs, 22% received three drugs, while 7% received ≥4 drugs. The therapy was effective in only 57% of subjects. We observed no differences in biochemical and clinical parameters between those who responded to the therapy and those who failed to do so. Calcium channel blockers constituted the most frequently administered class of drugs [73% of children; in 43 out of 48 (90%) combined with other drugs, but in 11 out of 24 (46%) as a monotherapy]. In monotherapy, angiotensin-converting enzyme inhibitors and calcium channel blockers were administered most frequently.

Conclusion. We conclude that the incidence of hypertension in dialysis children in Poland is high (55%). The effectiveness of antihypertensive treatment is rather low (58%) and the choice of drugs is limited.

Keywords: antihypertensive therapy; arterial hypertension; children; dialysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.