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NDT Advance Access originally published online on December 2, 2005
Nephrology Dialysis Transplantation 2006 21(3):701-706; doi:10.1093/ndt/gfi302
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Original Articles: Clinical Nephrology

Evidence against a contribution of conventional urine risk factors to de novo ESRD renal stones

Nicole Stankus, Elaine Worcester, Mary Hammes and Fredric L. Coe

Section of Nephrology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue MC 5100, Chicago, IL 60637, USA

Correspondence and offprint requests to: Nicole Stankus, Section of Nephrology, Department of Medicine, University of Chicago, 5841 South Maryland Avenue MC 5100, Chicago, IL 60637, USA. Email: nstankus{at}medicine.bsd.uchicago.edu

Background. The authors measured urine and blood stone risk factors in African-American (AA) haemodialysis (HD) patients with new onset of stones during dialysis.

Methods. Patients with nephrolithiasis (NL) newly manifested during dialysis were matched by age, sex and urine output and dialysis duration to AA HD patients without history or symptoms of stones. Two 24 h urine and serum samples were collected and analysed for conventional stone risk factors.

Results. Three percent of the patients formed new stones while on HD; none had formed stones prior to end-stage renal disease. Newly onset NL patients had higher urine citrate and lower serum potassium levels than HD patients without stones.

Conclusion. Usual stone risk factors did not correlate with new stones during dialysis.

Keywords: African-Americans; haemodialysis; kidney calculi; kidney failure


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