Individualizing anaemia treatment: a discussion of case histories
University of Western Ontario, London, Ontario, Canada
Correspondence and offprint requests to: Dr Norman Muirhead, London Health Science Center, Department of Nephrology, PO Box 5339, 339 Windermere Road, London, Ontario, N6A 5A5, Canada. Email: Norman.Muirhead{at}lhsc.on.ca
Current guidelines give evidence-based advice on how best to manage anaemia in patients with renal disease, but these guidelines do not consider individual patient needs, so tailoring anaemia management to each patient still remains a challenge for the treating physician. Two case studies are described that illustrate some of the key factors that need to be considered. The first case emphasizes that haemoglobin (Hb) targets recommended in current guidelines may not suit all patients. The patient had been stably maintained on subcutaneous epoetin therapy with an average Hb concentration of >13.0 g/dl because he developed angina symptoms when his Hb level fell to 12.2 g/dl. Iron deficiency was identified as the likely cause of falling Hb in this patient. After the patient's iron supplementation was increased, his Hb level was normalized back to >13.0 g/dl without increasing the epoetin dose, and the angina symptoms were resolved. The second case involved a pre-dialysis patient with diabetes, who required a higher dose of epoetin after beginning concomitant antihypertensive treatment with an angiotensin-converting enzyme inhibitor. Previously, the treatment of renal anaemia in pre-dialysis patients has not been the focus of attention. Two ongoing randomized controlled trials have been designed to study early initiation of epoetin treatment in pre-dialysis patients and will provide much needed information in this area.
Keywords: anaemia; cardiovascular; epoetin; haematocrit; haemoglobin; pre-dialysis; target
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  J. B. Wish and D. W. Coyne Use of Erythropoiesis-Stimulating Agents in Patients With Anemia of Chronic Kidney Disease: Overcoming the Pharmacological and Pharmacoeconomic Limitations of Existing Therapies Mayo Clin. Proc., November 1, 2007; 82(11): 1371 - 1380. [Abstract] [Full Text] [PDF]
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