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NDT Advance Access originally published online on May 26, 2005
Nephrology Dialysis Transplantation 2005 20(9):1932-1935; doi:10.1093/ndt/gfh912
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Original Article

Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patients

Kenichiro Kojima, Kuniyoshi Oda, Hitoshi Homma, Kazushi Takahashi, Yoshiko Kanda, Taketoshi Inokami and Shunya Uchida

Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

Correspondence and offprint requests to: Kenichiro Kojima, Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. Email: kojima{at}med.teikyo-u.ac.jp

Background. Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients.

Methods. We enrolled seven patients who were on regular haemodialysis and had sustained eosinophilia. White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers.

Results. Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. CD8-positive lymphocyte counts and serum IgE levels were unaltered. Crossover tests in two cases reproduced the higher eosinophilia within 4 weeks after returning to the original non-vitamin E-bonded dialyzer.

Conclusion: Vitamin E-bonded dialyzers may ameliorate eosinophilia through a mechanism mediated by a decrease in IL-5 secretion by CD4-positive lymphocytes.

Keywords: CD4-positive lymphocyte; eosinophilia; haemodialysis; IL-5; vitamin E-bonded dialyzer


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