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NDT Advance Access originally published online on June 21, 2005
Nephrology Dialysis Transplantation 2005 20(9):1874-1879; doi:10.1093/ndt/gfh928
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Original Article

Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients

Christine Fumeron1, Thao Nguyen-Khoa2,3, Claudine Saltiel1, Messeret Kebede2, Claude Buisson1, Tilman B. Drüeke3, Bernard Lacour2 and Ziad A. Massy4

1 AURA Centre Henri Küntziger, 2 Biochemistry A Laboratory and 3 INSERM U507, Necker Hospital, Paris, 4 Divisions of Clinical Pharmacology and Nephrology, INSERM ERI-12, Amiens University Hospital and University of Picardie, Amiens, France

Correspondence and offprint requests to: Professor Ziad A. Massy, MD, PhD, Division of Clinical Pharmacology and Nephrology, INSERM ERI-12, University of Picardie and Amiens University Hospital, CHU Amiens South, Av René Laennec, 80054, Amiens, France. Email: massy{at}u-picardie.fr

Background. There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients.

Methods. We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 mg three times per week) for 2 months on well-defined oxidative and inflammatory markers in 33 chronic haemodialysis (HD) patients.

Results. Normalization of plasma total vitamin C and ascorbate levels by oral vitamin C supplementation did not modify plasma levels of carbonyls, C-reactive protein and albumin, or erythrocyte concentrations of reduced and oxidized glutathione.

Conclusion. Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined.

Keywords: dialysis; inflammation; oxidative stress; vitamin C


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