Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Grekas, D. M.
Right arrow Articles by Tourkantonis, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grekas, D. M.
Right arrow Articles by Tourkantonis, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1987) 2: 179-182
© 1987 European Renal Association-European Dialysis and Transplant Association

research-article

Effect of Nifedipine in the Protection of Renal Function During In Situ Preservation

D. M. Grekas, H. N. Kalekou, S. Christodoulou and A. Tourkantonis

First Medical Department, Renal Unit, University Hospital Ahepa Thessaloniki, Greece

Correspondence and offprint requests to: Correspondence and offprins requests to: D. M. Grekas, First Medical Department, Renal Unit, University Hospital Ahepa, Thessaloniki, Greece

In an experimental study on six healthy dogs both kidneys were exposed and subjected to 1 h of ischaemia by clamping both renal vessels. To the left renal artery, 300 ml of cold (4°C) Euro-Collins solution in which nifedipine (Bay a 1040—20 µg/kg per min) was diluted, was infused for 15 min. Simultaneously 300ml of cold Euro-Collins solution plus 20 µg/kg per min of placebo (Bay a 1040—placebo) was infused in the right renal artery. The 1 h of ischaemia was divided in a 15-min period of cold ischaemia and 45 min of warm ischaemia, at the end of which both clamps were removed. During the 2 h (4x30 min) following the removal of the clamps, urine volume, urea and creatinine clearances, urine sodium concentration, sodium fractional excretion (%) and urine/plasma osmolality ratio measurements were made and results compared to the pre-ischaemia values. Both kidneys were then removed for histological study.

The nifedipine group restored diuresis of 0.43±0.23 ml/min within 30 min, while this degree of diuresis (0.64±0.16 ml/min) was achieved by the placebo group at 120 min. Urine volume as well as creatinine and urea clearances of the nifedipine group were significantly higher in all studied periods compared to the placebo group (P<0.01 or P<0.025). Urine sodium and FENa (%) were not different between the two groups, and urine/plasma osmolality ratio was above 1.1 in all studied periods for both groups. The microscopic study did not show any significant differences between the two groups. We conclude that nifedipine is effective in the protection of renal function when it is administered during experimental in situ preservation.

Keywords: In situ presentation; Nifedipine; Renal ischaemia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.