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Nephrol Dial Transplant (1987) 2: 169-171
© 1987 European Renal Association-European Dialysis and Transplant Association

research-article

Increased Free-Radical Activity During Haemodialysis?

E. R. Maher1, J. F. A. Wickens3, J. F. A. Griffin3, P. Kyle2, J. R. Curtis1 and T. L. Dormandy3

1Department of Medicine, Charing Cross Hospital UK 2Department of Haematology, Charing Cross Hospital UK 3Department of Chemical Pathology, Whittington Hospital London, UK

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr E. R. Maher, Department of Medicine, Charing Cross Hospital, Fulham Palace Road, London W68RF

Free-radical activity was studied in patients on maintenance haemodialysis by measuring plasma octadeca-9, 11-dienoic acid (9,11-LA'), a dieneconjugated derivative of linoleic acid. Baseline values of 9,11-LA' (esterified as phospholipids and as free fatty acids) in 51 haemodialysis patients were similar to that of normal control subjects. However, during haemodialysis there was a highly significant (P<0.001) increase in 9,11-LA' in all 13 patients studied, which reached a peak 30 mm after haemodialysis was started and then declined. The rise in plasma 9,11-LA' may be due to free radicals generated by activated neutrophils. Abnormal free-radical activity may be partly responsible for some haemodialysis-related complications, including pulmonary dysfunction in early haemodialysis.

Keywords: Free radicals; Haemodialysis; Leucopenia; Hypoxia, Heparin


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