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Nephrol Dial Transplant (1987) 2: 158-160
© 1987 European Renal Association-European Dialysis and Transplant Association

research-article

Plasma Concentrations of Atrial Natriuretic Peptide in Relation to Body Fluid Status in Chronic Uraemia

G. Cannella1,, A. Rodella2, G. Brunori1, M. Gaggiotti1, M. Sandrini1 and R. Maiorca1

1Department of Nephrology, Spedali Civili, and Department of Nephrology, School of Medicine, University of Brescia Italy 2Department of Chemistry, School of Medicine, University of Brescia Italy

Correspondence and offprint requests to: Correspondence and offprint requests to: Dr G Cannella, Department of Nephrology, Spedali Civili, 25100 Brescia, Italy

Basal plasma {alpha}-human natriuretic peptide ({alpha}-hANP) values were found to be significantly higher in 7 fluid-overloaded chronic dialysis patients than in 13 non-dialysed renal patients without extracellular fluid (ECF) expansion. Iso-osmotic reduction of the body weight by a single 3-h ultrafiltration caused {alpha}-hANP to decrease significantly in all anuric patients to values comparable to those of non-dialysed subjects. In this latter group, however, there was a significant inverse relationship between {alpha}-hANP and glomerular filtration rate but not between {alpha}-hANP and total blood volume. These findings suggest that both ECF expansion and impaired renal removal of {alpha}-hANP might be responsible for the high {alpha}-hANP in chronic uraemia.

Keywords: Atrial natriuretic peptide; Body-fluid removal; Chronic uraemia


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