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Nephrol Dial Transplant (1987) 2: 149-153
© 1987 European Renal Association-European Dialysis and Transplant Association

research-article

High-Density Lipoproteins in Untreated Idiopathic Nephrotic Syndrome Without Renal Failure

J. Joven1,, J. Rubiés-Prat2, E. Espinel3, M. R. Ras4 and L. Piera3

1Department of Medicine, Universidad de Barcelona Reus, Spain 2Department of Medicine, Hospital Germans Trias i Pujol, Universidad Autónoma de Barcelona Spain 3Department of Nephrology, Hospital Valle Hebrón Barcelona, Spain 4Department of Biochemistry, Hospital Valle Hebrón Barcelona, Spain

Correspondence and offprint requests to: Correspondence and offprint requests to: J. Joven, Department of Medicine, Universidad de Barcelona, 43201 Reus, Spain

Serum apoprotein A-I and lipid composition of high-density lipoproteins in 14 adults and 9 children with idiopathic untreated nephrotic syndrome without renal failure were studied. Serum apoprotein A-I in adults was significantly raised compared to a control group (1.72±0.49 and 1.45±0.15 g/l, Mean±SD, respectively); a similar trend was observed in children (1.88±0.62 and 1.52±0.21 g/l, respectively). High-density lipoprotein cholesterol was normal in both groups of patients (1.19±0.30 and 1.50±0.48mmol/l in adults and in children, respectively), whereas high-density lipoprotein phospholipids were decreased in adults and increased in children. In addition, apoprotein A-I: high-density lipoprotein cholesterol ratios in both groups of patients were significantly increased with respect to their control groups. These alterations suggest the existence of qualitative changes in high-density lipoprotein composition. Despite other associated risk factors, and particularly from the point of view of the ‘high-density lipoprotein hypothesis’, our patients with untreated nephrotic syndrome without renal failure seem not to be at a higher coronary risk.

Keywords: Apoprotein A-I; Cholesterol; High-density lipoproteins; Nephrotic syndrome; Phospholipids; Triglycerides


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