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Nephrol Dial Transplant (2004) 19: IV45-IV47
Nephrol Dial Transplant Vol. 19 Suppl 4 © ERA–EDTA 2004; all rights reserved

The long-term consequences of living-related or unrelated kidney donation

Claudia Sommerer1, Christian Morath1, Joachim Andrassy2 and Martin Zeier1

1 Department of Medicine, Division of Nephrology University of Heidelberg, Germany and 2 Department of Surgery, University of Wisconsin, Madison, WI, USA

Correspondence and offprint requests to: Martin Zeier, MD, Department of Medicine, Division of Nephrology, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany. Email: martin_zeier{at}med.uni-heidelberg.de

Abstract

Since the frequency of living-related and unrelated kidney donation has increased in the past decade, the risk of uninephrectomy should not be neglected. Major complications after kidney donation are rare. No serious problems like infection or bleeding are common with an overall perioperative complication rate of 14%. Risk of long-term mortality is lower compared to the expected mortality. Little decrease of glomerular filtration rate immediately after transplantation occurs with no further decline. Risk of end-stage renal failure in living donors is ~0.2–0.5%. Only a few patients develop proteinuria. After age adjustment, no increase of blood pressure is noted. The benefit of living kidney transplantation is superseding the potential risks. After careful work-up of the donor short- and long-term risks are minimal.

Keywords: blood pressure; living related; living kidney donation; proteinuria; renal transplantation; uninephrectomy


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