Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Encke, J.
Right arrow Articles by Sauer, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Encke, J.
Right arrow Articles by Sauer, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2004) 19: IV22-IV25
Nephrol Dial Transplant Vol. 19 Suppl 4 © ERA–EDTA 2004; all rights reserved

Immunosuppression and modulation in liver transplantation

Jens Encke1, Waldemar Uhl2, Wolfgang Stremmel1 and Peter Sauer1

1 Department of Internal Medicine IV, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany and 2 Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany

Correspondence and offprint requests to: Jens Encke, MD, Department of Internal Medicine IV, Gastroenterology, Hepatology, Infectious Diseases, Intoxications, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany. Email: Jens_Encke{at}med.uni-heidelberg.de

Abstract

Recent advances in immunosuppressive drug regimens have changed the outcome after liver transplantation significantly in the last two decades. However, chronic rejection and long-term graft survival remains a major problem. Side effects like drug-induced nephrotoxicity, hypertension, osteoporosis, hyperlipidaemia and neuropathy of some immunosuppressive agents play an essential role in long-term allograft and patient survival. This review outlines the current treatment of short- and long-term immunosuppression in liver transplanted patients, it summarizes the treatment of acute and chronic rejection, describes the complications and side effects of immunosuppressive therapy and points out the current use of immunosuppressive therapy in living-related liver transplantation.

Keywords: antiproliferative agents; calcineurin inhibitors; corticosteroids; immunosuppression; liver transplantation; living-related liver transplantation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.