NDT Advance Access originally published online on June 8, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Nephrol Dial Transplant (2004) 19: 2095-2100
Nephrol Dial Transplant Vol. 19 No. 8 © ERA-EDTA 2004; all rights reserved
Original Article
Plasma ghrelin levels in patients undergoing haemodialysis and peritoneal dialysis
1 Division of Nephrology, 2 Division of Endocrinology and 3 Division of Laboratory, Hospital Juan Canalejo, A Coruña, Spain and 4 Department of Medicine, Health Sciences Institute, University of A Coruña, Spain
Correspondence and offprint requests to: Miguel Pérez Fontán, MD, Division of Nephrology, Hospital Juan Canalejo, Xubias 84, 15006 A Coruña, Spain. Email: mfontan{at}canalejo.org
Background. Ghrelin has been characterized as a relevant physiologic regulator of appetite and body weight in humans. However, the potential relationships between ghrelin levels, inflammation and malnutrition in dialysis patients have not been adequately studied.
Methods. We used a cross-sectional design to study 20 haemodialysis (HD) and 21 peritoneal dialysis (PD) patients, and compared their plasma ghrelin (PGhr) levels with that of an age-matched control group. We also explored correlations between ghrelin and selected hormonal, renal adequacy, nutritional and inflammation markers in both groups.
Results. PGhr levels were higher in HD (median 119.8 pg/ml, range 71.1–333.7, P = 0.001) and PD (99.3, range 45.8–578.5, P = 0.045) patients than in healthy controls (78, range 29–158) (HD vs PD, not significant). Ghrelin levels were strongly and inversely correlated with age (r = –0.46, P = 0.02 for patients; r = –0.61, P = 0.001 for controls). Except for a positive correlation between ghrelin and growth hormone (r = 0.48, P = 0.002), univariate analysis failed to detect associations between PGhr and the measured hormonal values, renal adequacy, nutritional indicators and markers of inflammation. However, multivariate analysis revealed significant inverse correlations between PGhr levels and nutritional markers, including subjective global assessment (P = 0.013), albumin (P = 0.001), transferrin (P = 0.01) and protein nitrogen appearance (as an estimate of protein intake) (P = 0.035), after controlling for the confounding effect of age.
Conclusions. PGhr levels were moderately and similarly increased in patients undergoing HD and PD. Age was a strong determinant of PGhr levels, both in uraemic patients and in healthy controls. Dialysis adequacy, residual renal function and inflammation did not appear to influence ghrelin levels in these patients. The negative correlation between PGhr and nutritional markers suggests that low dietary intake causes increases in ghrelin secretion in dialysis patients.
Keywords: ghrelin; haemodialysis; inflammation; malnutrition; peritoneal dialysis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Perez-Fontan, F. Cordido, A. Rodriguez-Carmona, M. Penin, H. Diaz-Cambre, A. Lopez-Muniz, S. Sangiao-Alvarellos, and J. Garcia-Buela Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure Nephrol. Dial. Transplant., November 1, 2008; 23(11): 3696 - 3703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kumpers, R. Horn, G. Brabant, A. Woywodt, M. Schiffer, H. Haller, and M. Haubitz Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis Rheumatology, April 1, 2008; 47(4): 484 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wynne, K. Giannitsopoulou, C. J. Small, M. Patterson, G. Frost, M. A. Ghatei, E. A. Brown, S. R. Bloom, and P. Choi Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis: A Randomized, Placebo-Controlled Trial J. Am. Soc. Nephrol., July 1, 2005; 16(7): 2111 - 2118. [Abstract] [Full Text] [PDF]
|
|