Skip Navigation


NDT Advance Access originally published online on May 18, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/7/1866    most recent
gfh141v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Griva, K.
Right arrow Articles by Newman, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griva, K.
Right arrow Articles by Newman, S. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2004) 19: 1866-1874
Nephrol Dial Transplant Vol. 19 No. 7 © ERA-EDTA 2004; all rights reserved

Original Article

Neuropsychological performance after kidney transplantation: a comparison between transplant types and in relation to dialysis and normative data

Konstadina Griva, Sunita Hansraj, Derek Thompson, Dakshina Jayasena, Andrew Davenport, Michael Harrison and Stanton P. Newman

Centre for Behavioural and Social Sciences in Medicine, Division of Medicine, University College London, London, UK

Correspondence and offprint requests to: Professor Stanton P. Newman, Centre for Behavioural and Social Sciences in Medicine, Division of Medicine, University College London, Wolfson Building, 48 Riding House Street, London W1N 8AA, UK. Email: s.newman{at}ucl.ac.uk

Background. Neuropsychological (NP) performance after kidney transplantation (TX) has received little attention. This study compared NP functioning between dialysis and transplant patients and between living-related donor (LRD) and cadaver (CAD) transplant recipients. The association between immunosuppressive medication and NP outcomes was also examined.

Methods. One hundred and seventeen transplant recipients (25 LRD and 92 CAD patients) and 145 dialysis patients (77 haemodialysis and 68 peritoneal dialysis) were administered an NP test battery to assess learning and verbal recall, attention and concentration, and psychomotor abilities/speed. Biochemical markers of renal function were also assessed.

Results. Overall, transplant patients showed normal cognitive functioning in all domains assessed. NP performance was found to be equivalent in both transplant groups and in patients on cyclosporin and those on tacrolimus. ANCOVAs showed that TX patients performed significantly better than dialysis patients on selective NP tests, i.e. the two memory tasks and two out of the four tests of attention. No differences were found in motor tasks.

Conclusions. Our results reveal no evidence of NP deficits in TX patients. The NP advantage of TX relative to dialysis is evident mainly in verbal memory.

Keywords: cadaver; dialysis, functioning; living-related donor; neuropsychological; renal transplantation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
S. Gelb, R. J. Shapiro, A. Hill, and W. L. Thornton
Cognitive outcome following kidney transplantation
Nephrol. Dial. Transplant., March 1, 2008; 23(3): 1032 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Griva, D. Thompson, D. Jayasena, A. Davenport, M. Harrison, and S. P. Newman
Cognitive functioning pre- to post-kidney transplantation--a prospective study
Nephrol. Dial. Transplant., November 1, 2006; 21(11): 3275 - 3282.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.