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Nephrol Dial Transplant (2004) 19: 969-971
Nephrol Dial Transplant Vol. 19 No. 4 © ERA-EDTA 2004; all rights reserved

Brief Report

No association of G-463A myeloperoxidase gene polymorphism with MPO–ANCA-associated vasculitis

Anette Fiebeler1, Stefan Borgmann3, Alexander Woywodt2, Hermann Haller2 and Marion Haubitz2

1Division of Nephrology, Franz-Volhard-Clinic, Berlin, HELIOS, 2Division of Nephrology, Hannover Medical School, Hannover and 3Division of Medical Microbiology University of Tübingen, Germany

Correspondence and offprint requests to: Marion Haubitz, MD, Department of Nephrology, Medical School Hannover, D-30623 Hannover, Germany. Email: haubitz.marion{at}mh-hannover.de

Background. The activation of neutrophils and monocytes by ANCA, resulting in the release of reactive oxygen species and proteases like myeloperoxidase (MPO), is essential to the pathogenesis of ANCA-associated vasculitis. As the A allele of the G-463A MPO gene polymorphism is associated with diminished activity of MPO, it is conceivable that the presence of this allele protects against MPO–ANCA-associated vasculitis.

Methods. Allelic frequencies of the G-463A polymorphism were studied in 119 ANCA-associated vasculitis patients, 48 with MPO–ANCA and 71 with proteinase 3 (PR3)–ANCA.

Results. Allelic frequencies of MPO G-463A promoter polymorphism did not differ between MPO–ANCA- and PR3–ANCA-associated vasculitis patients. Moreover, allelic distribution was similar to that of the normal population.

Conclusions. The data suggest that G-463A polymorphism does not seem to contribute to either MPO–ANCA- or PR3–ANCA-associated vasculitis formation.

Keywords: ANCA; microscopic polyangiitis; myeloperoxidase; polymorphism; vasculitis; Wegener's granulomatosis


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