Skip Navigation


NDT Advance Access originally published online on July 20, 2004
Nephrology Dialysis Transplantation 2004 19(10):2513-2518; doi:10.1093/ndt/gfh405
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/10/2513    most recent
gfh405v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Delles, C.
Right arrow Articles by Schmieder, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delles, C.
Right arrow Articles by Schmieder, R. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant Vol. 19 No. 10 © ERA-EDTA 2004; all rights reserved

Original Article

Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes

Christian Delles, Markus P. Schneider, Sebastian Oehmer, Ingrid Fleischmann, Erwin F. Fleischmann and Roland E. Schmieder

Department of Medicine IV, University of Erlangen-Nürnberg, Germany

Correspondence and offprint requests to: Professor Dr Roland E. Schmieder, Department of Medicine IV/4, University of Erlangen-Nürnberg, Krankenhausstr. 12, D-91054 Erlangen, Germany. Email: roland.schmieder{at}rzmail.uni-erlangen.de

Background. Reactive oxygen species play a major role in the development of endothelial dysfunction. It is as yet unspecified whether increased oxidative stress contributes to endothelial dysfunction of the renal vasculature in patients with type 2 diabetes.

Methods. Renal haemodynamics were studied in 20 patients with type 2 diabetes and arterial hypertension (age 62 ± 5 years) and 20 non-diabetic hypertensive patients at baseline and following infusions of the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA; 4.25 mg/kg); the substrate of nitric oxide synthase, L-arginine (100 mg/kg); and the antioxidant, vitamin C (3 g, co-infused with L-arginine 100 mg/kg).

Results. The response of renal plasma flow (RPF) to L-NMMA (–54 ± 62 and –45 ± 42 ml/min/1.73 m2; P = NS) and L-arginine (+46 ± 36 and +49 ± 25 ml/min/1.73 m2; P = NS) was not different between diabetic and non-diabetic patients. In contrast, vitamin C induced a more pronounced increase in RPF in diabetic than in non-diabetic patients when co-infused with L-arginine (+71±47 and +43±33 ml/min/1.73 m2; P<0.05).

Conclusions. The difference in the response of renal perfusion to an antioxidant suggests increased formation of reactive oxygen species and thereby reduced nitric oxide bioavailability in the renal vasculature of patients with type 2 diabetes.

Keywords: oxidative stress; renal perfusion; type 2 diabetes


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. P. Schneider, M. Ritt, U. Raff, C. Ott, and R. E. Schmieder
Gender is related to alterations of renal endothelial function in type 2 diabetes
Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3354 - 3359.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. P. Schlaich and R. E. Schmieder
Contribution of Endothelial Nitric Oxide to Blood Pressure in Humans
Hypertension, May 1, 2007; 49(5): e29 - e29.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Chen, R. J. Karne, G. Hall, U. Campia, J. A. Panza, R. O. Cannon III, Y. Wang, A. Katz, M. Levine, and M. J. Quon
High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H137 - H145.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.