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Nephrol Dial Transplant (2003) 18: VI52-VI58
© 2003 European Renal Association-European Dialysis and Transplant Association

Secondary minimal change disease

Richard J. Glassock

The Geffen School of Medicine at UCLA, California, USA

Correspondence and offprint requests to: Richard J. Glassock, MD, 8 Bethany, Laguna Niguel, CA 92677, USA. Email: glassock{at}cox.net

Abstract

The great majority of patients identified as having a ‘minimal change lesion’ accompanying the nephrotic syndrome have a primary or ‘idiopathic’ disorder. Nevertheless, it is quite apparent that a similar or identical lesion can appear consequent to a growing number of underlying diseases; it is then known as ‘secondary minimal change disease’. The predisposing conditions include neoplastic diseases, toxic or allergic reactions to drugs, infections, auto-immune disorders and other miscellaneous entities. These disorders are reviewed and catalogued in this contribution.

Keywords: drugs; infections; minimal change; minimal change disease; neoplasia; nephropathy; secondary nephrotic syndrome


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