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Nephrol Dial Transplant (2003) 18: VI26-VI29
© 2003 European Renal Association-European Dialysis and Transplant Association

Immune dysregulation in minimal change nephropathy

Peter W. Mathieson

Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK

Correspondence and offprint requests to: Professor Peter Mathieson, PhD, Academic Renal Unit, Southmead Hospital, Bristol BS 10 5NB, UK. Email: p.mathieson{at}bris.ac.uk

Abstract

Minimal change nephropathy (MCN) has been associated with a wide variety of abnormalities in the immune response of affected individuals. Many of these may be a consequence of the renal lesion, rather than a cause thereof. This article reviews some of these immunological phenomena and concentrates in particular on the imbalance between type 1 and type 2 cytokine responses, suggesting that there are plausible mechanisms whereby a type 2 cytokine bias could directly or indirectly cause MCN.

Keywords: immune dysregulation; minimal change disease; nephrotic syndrome


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