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Nephrol Dial Transplant (2003) 18: VI2-VI7
© 2003 European Renal Association-European Dialysis and Transplant Association

Derivation and differentiation of glomerular endothelial cells

Dale R. Abrahamson and Barry Robert

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Rainbow Boulevard, Kansas City, Kansas 66160-7400, USA

Correspondence and offprint requests to: Dale R. Abrahamson, PhD, Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KA 66160-7400, USA. Email: dabrahamson{at}kurnc.edu

Abstract

Data on the embryonic derivation of metanephric endothelial cells are reviewed, paying particular attention to results obtained from anterior chamber and intrarenal grafts of embryonic kidneys. Most of the evidence supports an intrinsic origin of the endothelium, which probably differentiates from metanephric mesenchyme. The roles of several growth factor receptor/ligand systems are also discussed, with an emphasis on the VEGF receptors, Flk1 and neuropilin-1.

Keywords: angiogenesis; differentiation; endothelial cells; Flk1; glomerulus; neuropilin-1; vasculogenesis; VEGF


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