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Nephrol Dial Transplant (2003) 18: III79-III80
© 2003 European Renal Association-European Dialysis and Transplant Association

Original Article

Molecular targets of hyperphosphataemia in chronic renal failure

Ken-Ichi Miyamoto, Mikiko Ito, Hiriko Segawa and Masashi Kuwahata

Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Japan

Dietary phosphate restriction can prevent or retard the progress of chronic renal failure (CRF) and secondary hyperparathyroidism. The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification. Phosphate retention rescues the phenotype of klotho mice. The level of expression of klotho RNA was greatly reduced in the kidneys of all CRF patients. Dietary Pi restriction induced klotho expression, which enhances the beneficial effect of Pi restriction in patients with CRF and/or on haemodialysis.

Keywords: chronic renal failure; dietary phosphate; hyperphosphataemia; klotho; secondary hyperparathyroidism

Correspondence and offprint requests to: Ken-Ichi Miyamoto PhD, Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Kuramoto-cho 3, Tokushima City 770-8503, Japan.


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M. H. Meyer, E. Dulde, and R. A. Meyer Jr.
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Physiol Genomics, June 17, 2004; 18(1): 4 - 11.
[Abstract] [Full Text] [PDF]


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