Nephrol Dial Transplant (2003) 18: 1549-1554
© 2003 European Renal Association-European Dialysis and Transplant Association
Moderate alcohol intake and renal function decline in women: a prospective study
1 The Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 2 Department of Epidemiology, Harvard School of Public Health and 3 Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Correspondence and offprint requests to: Eric L. Knight, MD, MPH, Channing Laboratory, Nurses’ Health Study, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA. Email: elknight{at}partners.org
Background. The impact of moderate alcohol consumption on renal function has important public health implications given the high prevalence of alcohol use. Experimentally, alcohol may adversely affect renal function, but clinical data are limited and no large, prospective studies have examined this issue.
Methods. In a prospective study of 1658 nurses enrolled in the Nurses’ Health Study, we sought to determine if there was an association between moderate alcohol consumption and rate of decline in renal function. Daily alcohol intake was measured in 1990, 1994 and 1998 using a detailed questionnaire. Maximum daily alcohol intake was measured in 1988. Creatinine, measured from blood samples provided in 1989 and 2000, was used to estimate glomerular filtration rate (GFR) and creatinine clearance (CCr).
Results. Compared to individuals with no alcohol intake, the odds ratios (ORs) for developing a 
25% estimated GFR decline were: 0.98 (95% CI: 0.72–1.32) for 0.1–4.9 g/day, 0.83 (95% CI: 0.56–1.21) for 5–14.9 g/day and 0.81 (95% CI: 0.50–1.31) for 15–59.9 g/day. For women with hypertension (n = 726), the ORs for a 25% estimated GFR decline were: 0.98 (95% CI: 0.53–1.21) for 0.1–4.9 g/day, 0.62 (95% CI: 0.34–1.12) for 5–14.9 g/day and 0.53 (95% CI: 0.25–1.12) for 15–59.9 g/day.
Conclusions. Moderate alcohol consumption had no substantial adverse effect on renal function in women over an 11 year follow-up period.
Keywords: alcohol; creatinine clearance; glomerular filtration rate; renal function; renal insufficiency
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