Nephrol Dial Transplant (2003) 18: 2170-2174
© 2003 European Renal Association-European Dialysis and Transplant Association
Brief Report
Association between albuminuria and proteinuria in the general population: the AusDiab Study
1Department of Nephrology, Monash Medical Centre, 2Department of Epidemiology and Preventive Medicine, Monash University and 3International Diabetes Institute, Victoria, Australia
Correspondence and offprint requests to: Dr Esther Briganti, FRACP Senior Lecturer, Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Alfred Hospital, Prahran, Victoria 3181, Australia. Email: Esther.Briganti{at}med.monash.edu.au
Background. The relationship between urinary albumin and total protein excretion and the appropriateness of one test over the other are unclear due to the paucity of large epidemiological studies of albuminuria and proteinuria. In screening for renal and cardiovascular disease, whether to measure albuminuria, proteinuria or both, is currently an unanswered question.
Methods. Random urine samples from 10 596 (94.2%) participants of the Australian Diabetes, Obesity and Lifestyle Study were tested for albuminuria (urine albumin:creatinine 
30 mg/g) and proteinuria (urine protein:creatinine 0.20 mg/mg). This study was a representative sample of the national non-institutionalized population drawn from 42 randomly selected urban and non-urban areas (census collector districts) across Australia.
Results. Among a representative cross-section of the Australian adult population, urine albumin excretion was strongly correlated with total protein excretion, particularly among the elderly, and those with diabetes mellitus, hypertension, obesity and renal impairment (P <0.001). Albuminuria performed well as a screening test for proteinuria: sensitivity 91.7% [95% confidence interval (CI) 87.7–94.5%], specificity 95.3% (95% CI 94.9–95.7%) and negative predictive value 99.8% (95% CI 99.7–99.9%). However, among those with proteinuria, 8% excreted albumin within the normal range.
Conclusions. While albuminuria may be a suitable test for general population screening for renal and cardiovascular disease, it should not replace testing for proteinuria in those with known or suspected renal disease.
Keywords: albuminuria; proteinuria; renal disease; screening
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Guy, J. K Borzomato, R. G Newall, P. A Kalra, and C. P Price Protein and albumin-to-creatinine ratios in random urines accurately predict 24 h protein and albumin loss in patients with kidney disease Ann Clin Biochem, November 1, 2009; 46(6): 468 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J Lamb, F. MacKenzie, and P. E Stevens How should proteinuria be detected and measured? Ann Clin Biochem, May 1, 2009; 46(3): 205 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Collier, M. C. Greenan, J. J Brady, B. Murray, and S. K Cunningham A study of the relationship between albuminuria, proteinuria and urinary reagent strips Ann Clin Biochem, May 1, 2009; 46(3): 247 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schuster, M. K Palmer, and M. Ditmarsch The MERCURY I open-label extension study -- subgroup analysis in patients with diabetes The British Journal of Diabetes & Vascular Disease, May 1, 2008; 8(3): 142 - 147. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Redon, F. Morales-Olivas, A. Galgo, M. A. Brito, J. Mediavilla, R. Marin, P. Rodriguez, S. Tranche, J. V. Lozano, C. Filozof, et al. Urinary Albumin Excretion and Glomerular Filtration Rate across the Spectrum of Glucose Abnormalities in Essential Hypertension J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S236 - S245. [Abstract] [Full Text] [PDF]
|
|