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Nephrol Dial Transplant (2002) 17: 71-72
© 2002 European Renal Association-European Dialysis and Transplant Association

Genes and Development

Aspects of the renal phenotype of adult {alpha}8 integrin-deficient mice

Andrea Hartner, Christian Haas, Kerstin Amann1 and R. Bernd Sterzel

Med. Klinik IV and 1 Institut für Pathologie, Universität Erlangen-Nürnberg, Germany

Abstract

Integrins mediate cell–matrix interactions which are important for organ development. In the kidney, {alpha}8 integrin is expressed during early nephrogenesis. In {alpha}8 gene-mutated mice, lack of {alpha}8 leads to unilateral or bilateral renal agenesis in part of the animals. We investigated surviving animals with one or two kidneys. These mice had significantly reduced renal mass and displayed higher blood pressure compared with the wild-type. Furthermore, most of them revealed urine concentration defects. Many {alpha}8-deficient mice also exhibited segmental malformations of the kidney with collapse or atrophy of tubuli and interstitial cell infiltrates. These data provide further evidence that {alpha}8 has important functions in renal development.

Keywords: {alpha}8 integrin; {alpha}8 integrin-deficient mice; extracellular matrix; renal morphology

Notes

Correspondence and offprint requests to: Andrea Hartner, PhD, Nephrologische Forschungslabors, Loschgestrasse 8, D-91054 Erlangen, Germany.


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