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Nephrol Dial Transplant (2002) 17: 59-61
© 2002 European Renal Association-European Dialysis and Transplant Association

Tubulogenesis

Renotropic role and therapeutic potential of HGF in the kidney

Kunio Matsumoto and Toshikazu Nakamura

Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan

Abstract

Hepatocyte growth factor (HGF) has mitogenic, morphogenic and anti-apoptotic activities on renal epithelial cells, and is a potential renotropin for renal regeneration. In chronic renal failure/fibrosis, HGF in the kidney declines in a manner reciprocal to the increase in transforming growth factor-ß (TGF-ß). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis, while HGF administration leads to remarkable attenuation, thus indicating the importance of the balance between HGF and TGF-ß in the pathogenesis and therapy of chronic renal failure. HGF is strongly considered as potential treatment for acute and chronic renal failure.

Keywords: acute renal failure; chronic renal failure; c-Met; HGF; renal regeneration; renotropin

Notes

Correspondence and offprint requests to: Toshikazu Nakamura, PhD, Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.


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