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Nephrol Dial Transplant (2002) 17: 23-24
© 2002 European Renal Association-European Dialysis and Transplant Association

Podocytes

Is podocyte shape controlled by the dystroglycan complex?

Kenichiro Kojima and Dontscho Kerjaschki

Department of Clinical Pathology, University of Vienna, Vienna, Austria

Abstract

{alpha}- and ß-dystroglycan were detected at the base of foot processes of human glomeruli by immunoelectron microscopy. Perfusion of isolated rat kidneys with the polycationic compound protamine sulfate was found to induce rapid (i.e. within 15 min) flattening of foot processes in an energy- and actin-dependent fashion. Here we provide evidence that (i) glomeruli possess large amounts of a specifically composed complex; (ii) this complex may undergo changes in human glomerular disease; and (iii) flattening of foot processes is directly associated with dissociation of laminin–dystroglycan complexes.

Keywords: dystroglycan; podocyte

Notes

Correspondence and offprint requests to: K. Kojima, Department of Clinical Pathology, University of Vienna-AKH, A-1090 Vienna, Austria.


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This article has been cited by other articles:


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J. B. Kopp
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