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Nephrol Dial Transplant (2002) 17: 15-16
© 2002 European Renal Association-European Dialysis and Transplant Association

IV.2.4 De novo renal disease after transplantation

Guidelines

A. Acute pyelonephritis is relatively frequent in the transplanted kidney and carries a risk of septicaemia. The condition should be recognized and the patient should be treated promptly in the hospital.

(Evidence level B)

B. After initiation of any drugs known to induce the development of interstitial nephritis in the transplant patient, it is recommended to monitor renal function and abnormalities in order to detect any side effects rapidly. If interstitial nephritis is observed, it is recommended to stop the offending drug, and to initiate appropriate treatment.

(Evidence level C)

C. De novo membranous nephropathy should be considered in cases of proteinuria and nephrotic syndrome after transplantation. Viral infection, such as HCV, should be excluded.

(Evidence level B)

D. In the case of the development of graft dysfunction in a transplant patient with Alport's syndrome, one should consider additionally the possibility of de novo anti-glomerular basement membrane (anti-GBM) glomerulonephritis.

(Evidence level C)


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