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Nephrol Dial Transplant (2002) 17: 11-15
© 2002 European Renal Association-European Dialysis and Transplant Association

IV.2.3 Non-alloimmune factors

Guidelines

A. Whereas immunological mechanisms dominate in the initiation and propagation of the injury that leads to chronic allograft dysfunction and nephropathy, there is circumstantial evidence that non-immunological factors, such as advanced donor age, hyperfiltration, overweight, delayed graft function, heavy proteinuria, smoking, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia, play a role as aggravating or progression factors. It is recommended to prevent or, if possible, treat all these factors.

(Evidence level B)

B. As arterial hypertension is very frequent among renal transplant patients and associated with increased graft (and patient) loss, it is recommended to aim at a blood pressure less than 130/85 mmHg in renal transplant patients and <125/75 mmHg in recipients with proteinuria >1 g/day.

(Evidence level A)


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