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Nephrol Dial Transplant (2002) 17: 30-34
© 2002 European Renal Association-European Dialysis and Transplant Association

HAEMODIALYSIS

Determinants of uraemic toxin removal

William R. Clark1,2, and Dayong Gao3

1 Renal Division, Baxter Healthcare Corp., McGaw Park, IL, 2 Nephrology Division, Indiana University School of Medicine, Indianapolis, IN and 3 Center for Biomedical Engineering, University of Kentucky, Lexington, KY, USA

Abstract

The inability to excrete a wide spectrum of toxins is one of the hallmarks of uraemia and is responsible for many of the signs and symptoms of this syndrome. Therefore, an understanding of the factors influencing uraemic toxin removal, during both the pre-dialysis and dialytic phases, is critically important. This review addresses many of these factors, which include the importance of preserved residual renal function and the effect of therapy frequency. In addition, specifically with respect to larger uraemic toxins, the importance of convection and treatment duration is discussed. All of these issues will be major considerations as new dialytic therapies for end-stage renal disease patients are developed and implemented.

Keywords: convection; diffusion; haemodialysis; peritoneal dialysis; solute

Notes

Correspondence and offprint requests to: William R. Clark, MD, Hemodialysis Research Laboratory, Renal Division, Baxter Healthcare Corporation, Wishard Hospital/Myers Building D711, 1001 West 10th Street, Indianapolis, IN 46202, USA.


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