Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ducloux, D.
Right arrow Articles by Chalopin, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ducloux, D.
Right arrow Articles by Chalopin, J.-M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2002) 17: 1674-1677
© 2002 European Renal Association-European Dialysis and Transplant Association

Homocysteine, nutritional status and insulin in renal transplant recipients

Didier Ducloux1,, Gérard Motte1, Nhu Uyen Nguyen2, Aboubakr Abdelfatah1, Roger Gibey3 and Jean-Marc Chalopin1

1 Service de Néphrologie et Transplantation Rénale, 2 Laboratoire d'Explorations Fonctionnelles Rénales, Métaboliques, et Endocriniennes and 3 Laboratoire de Biochimie, Hopital Saint Jacques, Besançon, France

Background. Hyperhomocysteinemia is an independent risk factor for the development of cardiovascular conditions in chronic stable renal-transplant recipients (RTR). Major determinants of plasma total homocysteine (tHcy) in RTR are renal function and folate levels. The data dealing with the possible regulation of the tHcy metabolism by insulin and nutritional status is conflicting in non-transplant populations.

Methods. We examined the relationship between tHcy, insulin and nutritional status in 103 chronic, stable RTR. Demographic, clinical, and biochemical parameters were assessed for each patient.

Results. Mean tHcy was 19.7±9.2 µmol/l (range 8.6–53). The tHcy was strongly related to creatinine clearance (r=0.55, P<0.0001). Fasting tHcy levels were negatively related to folate concentrations (r=-0.32, P=0.01). There was a positive relationship between tHcy and LDL-cholesterol (r=0.34, P=0.03) and a significant negative correlation between tHcy and insulin (r=-0.38, P=0.01). Fasting tHcy concentrations were significantly higher in the lower quartile of insulin concentration than in the upper quartile (27.7±12.7 vs 15.9±9.5, P=0.01). In multivariate analysis, tHcy was associated with serum creatinine (P=0.001), insulin (P=0.02) and folate concentration (P=0.03). Patients with the highest IGF-1 concentration had lower tHcy than patients with the lowest IGF-1 concentration (16.8±5.7 vs 23.3±11 µmol/l, P=0.01).

Conclusion. We observed an inverse relationship between insulin and tHcy in chronic, stable RTR.

Keywords: folate concentrations; hyperhomocysteinaemia; IGF-1; insulin; nutritional status; renal transplant patients; total homocysteine

Correspondence and offprint requests to: Dr Didier Ducloux, Department of Nephrology, Dialysis and Renal Transplantation, Saint Jacques Hospital, Besançon, France. Email: didier.ducloux{at}libertysurf.fr


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.