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Nephrol Dial Transplant (2001) 16: 8-11
© 2001 European Renal Association-European Dialysis and Transplant Association


Advanced glycation and lipoxidation end products: reactive carbonyl compounds-related uraemic toxicity

Toshio Miyata, Akira Saito, Kiyoshi Kurokawa and Charles van Ypersele de Strihou1

Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-11, Japan and 1 University of Louvain Medical School, Department of Nephrology, Cliniques Universitaires St-Luc, Brussels 1200, Belgium

Abstract

Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.

Notes

Correspondence and offprint requests to: Toshio Miyata, Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1143, Japan.


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