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Nephrol Dial Transplant (2001) 16: 1251-1255
© 2001 European Renal Association-European Dialysis and Transplant Association

Vitamin C improves endothelial dysfunction in renal allograft recipients

Michael J. A. Williams1,, Wayne H. F. Sutherland1, Maree P. McCormick1, Sylvia A. de Jong1, John R. McDonald2 and Robert J. Walker1

1 Departments of Medicine 2 Computer Science, University of Otago, Dunedin, New Zealand

Background. Endothelial function is impaired in renal allograft recipients but the effects of antioxidant vitamin therapy on endothelial function in such patients is unknown.

Methods. Thirteen renal allograft recipients were randomized to vitamin C or placebo in a double blind cross-over study design. Flow-mediated endothelium-dependent dilation and glyceryltrinitrate-induced endothelium-independent dilation of the brachial artery were assessed before and 2 h after oral administration of 2 g vitamin C or placebo.

Results. Plasma vitamin C levels increased from 33.5±17.0 µmol/l to 98.8±60.2 µmol/l after treatment (P=0.0001). Endothelium-dependent dilation improved (from 1.6±2.6 to 4.5±2.5%) after vitamin C administration but was unchanged after placebo (1.9±1.5 to 1.8±2.5%; P=0.003 for vitamin C vs placebo). There was no significant change in endothelium-independent dilation in response to vitamin C. Vitamin C was also associated with a significant increase in the lag time in dilute serum oxidation (P=0.001).

Conclusions. Vitamin C acutely improves flow-mediated, endothelium-dependent dilation and increases the resistance of lipoproteins in dilute serum to oxidation in renal transplant recipients.

Keywords: antioxidants; ascorbic acid; endothelium; transplantation

Correspondence and offprint requests to: M.J.A. Williams, Department of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand.


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