Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yonemura, K.
Right arrow Articles by Hishida, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yonemura, K.
Right arrow Articles by Hishida, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2000) 15: 668-672
© 2000 European Renal Association-European Dialysis and Transplant Association

Low free thyroxine concentratios and deficient nocturnal surge of thyroid-stimulating hormone in haemodialysed patients compared with undialysed patients

Katsuhiko Yonemura, Toshiaki Nakajima1, Takayuki Suzuki1, Shinichiro Ando2, Rieko Genma2, Hirotoshi Nakamura2 and Akira Hishida1

Hemodialysis Unit, 1 First Department of Medicine and 2 Second Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

Background. There is little information on the differences in pituitary–thyroid function between undialysed and haemodialysed patients.

Methods. Serum concentrations of free thyroxine (T4) and free triiodothyronine (T3), measured by enhanced chemiluminescence immunoassay, and thyroid-stimulating hormone (TSH) were compared in undialysed (n=22) and haemodialysed patients (n=85). The response of the serum TSH concentration to exogenously administered thyrotropin-releasing hormone (TRH) and circadian variation in serum TSH were also studied in the two groups.

Results. Serum free T4 concentration was significantly lower in haemodialysed than in undialysed patients (1.02±0.02 vs 1.33±0.06 ng/dl, P<0.0001). Serum concentrations of free T3 and TSH were essentially the same for the two groups. The response of serum TSH concentration to TRH was basically the same. Serum TSH concentration in undialysed patients during the night and in the morning were 142.4±15.4% and 121.7±4.1% of that during the day, the differences being significantly different. A nocturnal surge of TSH was not observed in haemodialysed patients.

Conclusions. Low serum free T4 concentration and a deficient nocturnal surge of TSH were found in haemodialysed patients compared with undialysed patients. The deficient nocturnal surge of TSH may contribute to the lower serum free T4 concentration in haemodialysed patients.

Keywords: chronic renal failure; haemodialysis; thyroid hormone; thyroid-stimulating hormone

Correspondence and offprint requests to: Katsuhiko Yonemura MD, PhD, Hemodialysis Unit, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, 431-3192, Japan.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.