Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Noel, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Noel, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrology Dialysis Transplantation, Vol 14, Issue 90003 53-57, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

Morphological features of primary focal and segmental glomerulosclerosis

L Noel
INSERM U 507, Laboratoire de Pathologie Rénale, Hôpital Necker, 161 rue de Sévres, 65015 Paris, France

Focal and segmental glomerulosclerosis (SGS) is one of the most common and non-specific patterns of glomerular injury encountered in human renal biopsies. The primary form can be considered when there is a nephrotic syndrome without other causes. The majority of authors agree that podocytes play a role in the development of segmental glomerulosclerosis. The lesion begins with cell hypertrophy, foot process effacement, cell body attenuation, pseudocyst formation, cytoplasmic overload with reabsorption droplets and finally detachment of the glomerular basement membrane (GBM). When the GBM is denuded, it comes into contact with the parietal epithelium and parietal epithelial cells will attach to the GBM, leading to a synechia and, finally, sclerosis. Along this zone, parietal epithelial cells rest on hyalin deposits. The origin of primary FSGS has not yet been elucidated. Genetic, racial and developmental factors, macrophages, viral factors and circulating factors are being explored and give encouraging results. Key words: focal and segmental glomerulosclerosis; podyctes; cytokines; genetic factors; viral factors; transplantation
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
A. Munkert, U. Helmchen, M. J. Kemper, M. Bubenheim, R. A. K. Stahl, and S. Harendza
Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs
Nephrol. Dial. Transplant., March 1, 2009; 24(3): 735 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. K. Berfield, A. Chait, J. F. Oram, R. A. Zager, A. C. Johnson, and C. K. Abrass
IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F138 - F147.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Shigehara, C. Zaragoza, C. Kitiyakara, H. Takahashi, H. Lu, M. Moeller, L. B. Holzman, and J. B. Kopp
Inducible Podocyte-Specific Gene Expression in Transgenic Mice
J. Am. Soc. Nephrol., August 1, 2003; 14(8): 1998 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Menjívar, M. Cárdenas, G. Ortiz, and J. Pedraza-Chaverrí
Fertility Diminution in Female Rats with Experimental Chronic Nephrosis
Biol Reprod, November 1, 2000; 63(5): 1549 - 1554.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.