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Nephrology Dialysis Transplantation, Vol 14, Issue 90001 55-57, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

Expression of bcl-2 and bax in glomerular disease

A Yoshimura, S Uda, K Inui, T Nemoto, Y Sugenoya, S Sharif, N Yokota, S Watanabe and T Ideura
Department of Medicine, Division of Nephrology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227, Japan; Corresponding author

Bcl-2 may account in part for the maintenance of hypercellularity in human glomerular diseases through preventing cell death and by counteracting bax which may be expressed to regulate excessive proliferation. This process is associated with the effect of PDGF B-chain expression. Bax expression may be important in the cell loss leading to glomerulosclerosis and TGF-{beta}1 participates in this process by increasing bax expression. Thus, the balance of bcl-2/bax expression may be critical in the course of human glomerular diseases.
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