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Nephrology Dialysis Transplantation, Vol 14, Issue 7 1673-1678, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

Glomerular filtration rate estimated from the uptake phase of 99Tc-DTPA renography in chronic renal failure

L Petersen, , J Petersen, U Talleruphuus, M Moller, S Ladefoged, J Mehlsen and H Jensen
Department of Nephrology, Hvidovre Hospital, Hvidovre, Denmark; Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Frederiksberg, Denmark; Corresponding author at: Hovmarksvej 39, DK-2920 Charlottenlund, Denmark

Background: The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea. Methods: Fifty patients with reduced renal function (serum creatinine between 150 and 600 &mgr;mol/l) were enrolled in the study. GFR was estimated from the uptake phase of 99mTc-DTPA renography (GFRDTPA). The renal clearance of 51Cr-EDTA (GFREDTA was used as the reference method. Creatinine clearance (CCr), urea clearance (CUr) and the mean of urea and creatinine clearance (C(Cr+Ur)/2) were also calculated from urine collected during a period of 24 h. Limits of agreement were used for method comparison. Conclusion: The limit of agreement between GFRDTPA and GFREDTA was 2±17 ml/min. The mean difference did not deviate significantly from zero. The other clearance techniques had larger limits of agreement and a mean difference significantly different from zero. Furthermore, CUr and C(Cr+Ur)/2 had systematic deviations of the differences, indicating that CUr and C(Cr+Ur)/2 are poor estimates of GFR. Conclusion: The limit of agreement between GFRDTPA and GFREDTA are acceptable and, therefore, GFR estimated from 99mTc-DTPA renography is acceptable for clinical use in patients with reduced renal function. Furthermore, the method is simple and less time consuming compared with renal clearance techniques. Key words: glomerular filtration rate; renal insufficiency; renography
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