Nephrology Dialysis Transplantation, Vol 14, Issue 6 1517-1520, Copyright © 1999 by Oxford University Press
A Deman, P Peeters, J Sennesael and B cooperating group
Background: The effect of hydroxyethyl starch (HES) on
early allograft function was examined retrospectively in a cohort of 119
renal transplantations realized by local organ exchange between four
cooperating centres. Methods: After exclusion, 109
transplant procedures were subdivided in three groups according to donor
colloid loading: (i) HS-group (Haes steril® 6%, mean volume (SD):
979 (946) ml, n=20); (ii) PS-group [Plasmasteril®, mean volume
(SD): 769 (411) ml, n=16]; and (iii) control group (gelatin-albumin, n=73).
Results: Delayed graft function (DGF), defined as the
need for dialysis during the first post-transplant week, occurred in 3/20
(15%) cases in the HS-group, in 5/16 (31%) cases in the PS-group and in
14/73 (19%) cases in the control group (P=0.450). Uni- and multivariate
analysis revealed older donor age (P=0.001) and kidney preservation with
histidine-tryptophan-ketoglutarate (HTK) (P=0.001) as the only factors
associated with a higher incidence of DGF. Conclusion:
Renal function as measured by daily serum creatinine concentration and 24 h
urinary output up to 14 days post-transplantation in the HS-group was
comparable with that of controls. The higher serum creatinine observed
during the first seven post-transplant days in the PS-group could be
related to higher donor age and haemodynamic instability and recipient male
preponderance, rather than to HES itself. Key words:
delayed graft function; hydroxyethyl starch; kidney transplantation
ORIGINAL ARTICLES
Hydroxyethyl starch does not impair immediate renal function in kidney transplant recipients: a retrospective, multicentre analysis
Renal Unit, Academisch Ziekenhuis, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussel, Belgium; Corresponding author
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